Nanobubbles, encompassing various gases, are particularly studied for therapeutic purposes, with oxygen being the most extensively researched. Nanobubble immersion therapy emerges as a promising form of oxygen therapy.
For a detailed comparison between nanobubble therapy, hyperbaric oxygen therapy, and oval.bio’s unique triumvirate of oxygen saturation, check [5].
Promising research highlights nanobubbles’ therapeutic benefits in wound healing [1], reducing visceral fat [2], and slowing bone loss [3].
In oxygen nanobubble therapy research, the focus is often on diseases requiring targeted oxygen delivery to specific body regions. Studies reveal that nanobubble oxygen therapy effectively delivers controlled oxygen levels [4, 5, 6] and penetrates the blood-brain barrier [7].
While nanobubble therapy is a relatively new concept, pioneering studies affirm the legitimate efficacy of oxygen nanobubbles in delivering oxygen to the body.
The importance of targeted oxygen therapy lies in oxygen’s fundamental role in cellular function, vital for the survival of all cells in the body. Oxygen is crucial for cellular respiration, a process in which oxygen and glucose react to produce ATP, the primary molecular energy source for cellular functions. ATP demonstrates extensive effects, enhancing cognitive function [8], promoting wound healing [9], and accelerating muscle recovery [10].
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Unraveling Cellular Oxygen Sensitivity: Nobel-Winning Discoveries and the Triumvirate Oxygen Therapy Approach at oval.bio
Accepted in scientific circles was the sensitivity of cells to oxygen, yet the mechanisms behind it remained unknown. The groundbreaking discovery on how cells respond to oxygen won the 2019 Nobel Prize in Medicine, highlighting oxygen’s significant role in cellular function.
Researchers identified HIF, a transcription factor regulating oxygen-dependent responses, and HIF-1α, a key subunit, as crucial regulators of a cell’s oxygen response. These factors are receptive to hydroxylation, a process vital for detoxification in the liver and kidneys.
HIF-1α influences diverse biological processes, including energy metabolism, cell survival, and angiogenesis, underscoring the broad-ranging effects of oxygen. The Nobel Prize recognizes the study’s importance in advancing our understanding of and combatting serious diseases.
Due to oxygen’s paramount importance, oval.bio aims to fully saturate the body with its maximum potential through a unique triumvirate oxygen therapy. This approach delivers oxygen via three systems: digestive, circulatory (dermal), and respiratory. Users consume enriched nanobubble oxygen water, undergo dermal immersion, and breathe oxygen, optimizing oxygen intake through three methods.
To delve into the triumvirate and our novel oxygen therapy approach, visit [4].
Our efforts focus on maximizing user oxygen intake through these combined methods. The transcutaneous (dermal) method of dissolved oxygen saturation penetrates over 700 μm into tissue, reaching blood circulation. This contrasts with gaseous oxygen used in hyperbaric oxygen therapy, less potent and transdermally penetrable, with barriers hindering immediate body utilization.
The table below [4] illustrates the deeper penetration of liquid dissolved oxygen compared to gaseous oxygen. Liquid forms, like closed-cell foam and alginate catalyst, penetrate the skin more effectively, easily reaching the bloodstream.
Revolutionizing Oxygen Absorption: From Skin’s Natural Role to Synergistic Oxygen and Red Light Therapy at oval.bio
The concept of skin functioning as an oxygen absorber isn’t novel. Roe et al. also highlights that oxygen and carbon dioxide levels in preterm infants are 5-6 times higher than in adults (4), indicating the skin’s ability to absorb oxygen from a young age when lungs are not fully developed. Additionally, adult skin consumes up to 5 mL/min, and researchers suggest that topical dissolved oxygen devices can meet nearly the full physiological oxygen requirements of the skin.
For a more in-depth exploration of transcutaneous dissolved oxygen compared to simple gaseous oxygen, refer to [5].
At oval.bio, we integrate oxygen therapy with red light therapy, believing in their synergistic effect. The rationale is that our triumvirate of oxygen therapy maximizes the body’s oxygen saturation. Simultaneously, red light therapy enhances and energizes cell mitochondria. With ample oxygen concentrations, mitochondria efficiently process oxygen into ATP through cellular respiration. This allows users to harness the numerous benefits of increased ATP levels in the body. Consequently, we contend that the combined use of oxygen and red light surpasses the benefits of each used individually.
Sources:
[1] https://pubmed.ncbi.nlm.nih.gov/27804028/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607864/
[3] https://pubmed.ncbi.nlm.nih.gov/27896363/
[4] https://pubmed.ncbi.nlm.nih.gov/26769397/
[5] https://www.nature.com/articles/s41598-018-20363-8
[6] https://pubs.acs.org/doi/10.1021/acsami.0c07022
[7] https://www.sciencedirect.com/science/article/pii/S0301562919301310
[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257700/
[9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850226/
[10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213384/
[11] https://www.nobelprize.org/prizes/medicine/2019/press-release/
[12] https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3091
